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CAS RN: 64048-12-0 | 產品號碼: G0626
GANT 58
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| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 10MG |
NT$7,280
|
18 | 20 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | G0626 |
| 純度/分析方法 | >93.0%(qNMR) |
| 分子式 / 分子量 | C__2__4H__1__6N__4S = 392.48 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 64048-12-0 |
| Reaxys-RN | 47834 |
| MDL編號 | MFCD01103196 |
產品規格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 93.0 % |
| Melting point | 249.0 to 253.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 250 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
GANT 58: A Hedgehog/GLI (Hh/GLI) Signaling Pathway Inhibitor (Antagonist)
Hedgehog (Hh) signaling, which plays a critical role in cell proliferation and survival, has also been implicated in cancer initiation and progression. Glioma-associated oncogene (GLI) is an important nuclear transcription factor in Hh signaling and tumorigenesis. GANT 58 inhibits the Hedgehog/GLI (Hh/GLI) signaling pathway and induces apoptosis in cancer cell lines. (The product is for research purpose only.)
References
- Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
- Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells
- Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened (a review)
- Current trends in Hedgehog signaling pathway inhibition by small molecules (a review)
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