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CAS RN: 220904-83-6 | 產品號碼: G0609
| 產品號碼 | G0609 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__1__5H__8Br__2INO__2 = 520.95 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Air Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 220904-83-6 |
| Reaxys-RN | 8641129 |
| MDL編號 | MFCD09971042 |
產品規格
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 95.0 %(total of isomers) |
| NMR | confirm to structure |
性質
| 熔點 | 262 °C |
GHS
相關法規
| RTECS # | NM3249100 |
運輸資料
| HS編碼* | 2933.79-000 |
Application
GW5074: An Inhibitor of Raf-1 and LRRK2
GW5074 has been used as a potent and selective inhibitor of Raf-1 (c-Raf) which is a serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway.1,2) Recently, it has been reported that GW5974 is also an inhibitor of the autophosphorylation of leucine-rich repeat kinase 2 (LRRK2), which is a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain.3-6) GW5074 is of interest for studying Parkinson's disease (PD), because mutations in the gene encoding Parkinson’s protein LRRK2 indicate LRRK2 as promising therapeutic target for the treatment of PD. (The product is for research purpose only.)
References
- 1) The discovery of potent cRaf1 kinase inhibitors
- 2) Untying the regulation of the Raf-1 kinase (a review)
- 3) Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
- 4) Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
- 5) LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase
- 6) Development of LRRK2 Inhibitors for the Treatment of Parkinson's Disease (a review)
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