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CAS RN: 1405-41-0 | 產品號碼: G0383
補充產品訊息:
This product has not been tested and guaranteed for potency.
| 產品號碼 | G0383 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 1405-41-0 |
| 相關CAS RN | 1403-66-3 |
| PubChem Substance ID | 160871021 |
| MDL編號 | MFCD00270181 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Total Nitrogen | 8.0 to 10.0 % |
| Specific rotation [a]20/D | +107.0 to +121.0 deg(C=1, H2O)(calcd.on anh.substance) |
| Water | max. 18.0 % |
性質
| 比旋光 [α]D | 115° (C=1,H2O) |
| 溶解性（不溶於） | Ether, Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
相關法規
| RTECS # | LY2625000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Gentamicin: An Aminoglycoside Antibiotic with Potent Bactericidal Activities
Gentamicin, an aminoglycoside antibiotic, is isolated from Micromonospora purpurea, a genus of Gram-positive bacteria. It consists of a mixture of three isomers, gentamicin C1, gentamicin C1a and gentamicin C2. Gentamicin interacts with the 30S subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Gentamicin has activity against mostly Gram-negative bacteria including Pseudomonas, Proteus, Serratia, and the Gram-positive Staphylococcus. But, it is not used for Pneumococcus, Hemolytic streptococci, Bacteroides, Rickettsia and fungus. Gentamicin is widely used because of its potent bactericidal activities and less bacterial resistance, but it is well known to cause nephrotoxicity and hypacusis.
References
- The aminoglycosides
- Structural origins of gentamicin antibiotic action
- Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model
- Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it?
- Mesoporous SBA-15 HPLC evaluation for controlled gentamicin drug delivery
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