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CAS RN: 162359-56-0 | 產品號碼: F1018
Fingolimod Hydrochloride
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| 產品號碼 | F1018 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__9H__3__3NO__2·HCl = 343.94 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 200MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 162359-56-0 |
| 相關CAS RN | 162359-55-9 |
| Reaxys-RN | 7837310 |
| PubChem Substance ID | 253660828 |
| Merck Index(14) | 4083 |
| MDL編號 | MFCD00939512 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
性質
| 熔點 | 110 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | TY3130000 |
運輸資料
| HS編碼* | 2922.19-000 |
Application
Fingolimod hydrochloride (FTY720): An Immunomodulatory Agent Working as a Sphingosine 1-Phosphate Receptor Agonist
Fingolimod was first synthesized in 1992 by chemical modification of an immunosuppressive natural product, myriocin which is a metabolite of the fungus. Fingolimod hydrochloride (FTY720) is an orally active immunomodulatory agent, and inhibits lymphocyte emigration from lymphoid organs. Recent data show that FTY720 is a prodrug, and phosphorylated FTY720 is an agonist at sphingosine 1-phosphate (S1P) receptors. FTY720 is commonly used for the treatment of multiple sclerosis, an inflammatory disorder of the central nervous system. (The product is for research purpose only.)
References
- FTY720 Story. Its Discovery and the Following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology (a review)
- Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
- The immune modulator FTY720 targets sphingosine 1-phosphate receptors
- FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function (a review)
- Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis (a review)
- FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
考研文獻
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