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CAS RN: 93957-55-2 | 產品號碼: F0820
Fluvastatin Sodium Salt
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* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
補充產品訊息:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| 產品號碼 | F0820 |
| 純度/分析方法 | >98.0%(HPLC)(N) |
| 分子式 / 分子量 | C__2__4H__2__5FNNaO__4 = 433.46 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 93957-55-2 |
| 相關CAS RN | 93957-54-1 |
| PubChem Substance ID | 160870917 |
| Merck Index(14) | 4218 |
| MDL編號 | MFCD00929076 |
產品規格
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 %(calcd.on anh.substance) |
| Water | max. 6.0 % |
性質
| 溶解性（可溶於） | Methanol |
GHS
相關法規
| RTECS # | MJ9675100 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Fluvastatin Sodium Salt: A HMG-CoA Reductase Inhibitor with Anti-Oxidative Properties
Enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase catalyzes the rate-limiting step in cholesterol biosynthesis. Statins inhibit the action of HMG-CoA reductase resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. In addition, statins (in particular fluvastatin) have reported their anti-oxidative properties. Many statins are metabolized by cytochrome P450 3A4 (CYP3A4) while fluvastatin is metabolized by CYP2C9. (The product is for research purpose only.)
References
- Inhibition of cholesterol synthesis ex vivo and in vivo by fluvastatin, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase
- Structural mechanism for statin inhibition of HMG-CoA reductase
- Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits
- In vitro comparative inhibition profiles of major human drug metabolizing cytochrome P450 isoenzymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors
- The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions
考研文獻
文章/手冊
TCIMail
[TCIMAIL No.154] HMG-CoA Reductase Inhibitors (Statins)[Research Articles] Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes
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