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CAS RN: 571203-78-6 | 產品號碼: E1524
| 產品號碼 | E1524 |
| 純度/分析方法 | >98.0%(HPLC)(qNMR) |
| 分子式 / 分子量 | C__3__0H__3__1ClN__4O__4 = 547.05 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 571203-78-6 |
| Reaxys-RN | 14580272 |
| MDL編號 | MFCD09837984 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
性質
GHS
相關法規
運輸資料
| HS編碼* | 2933.59-000 |
Application
Erastin: Inducer of Ferroptosis
References
- 1) Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- 2) Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis
- 3) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Application
Erastin: A Ferroptosis Inducer
Erastin is a ferroptosis inducer. Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid reactive oxygen species. There are reports that erastin inhibits cystine uptake by the cystine/glutamate antiporter (system xc-), which helps maintain the redox state. This inhibition creates a void in the cell's antioxidant defenses and ultimately leads to iron-dependent oxidative death (ferroptosis). In addition, activation of ferroptosis results in the non-apoptotic destruction of certain cancer cells. (The product is for research purpose only.)
References
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- Ferroptosis: a novel anti-tumor action for cisplatin
- Broadening horizons: the role of ferroptosis in cancer (a review)
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