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CAS RN: 163222-33-1 | 產品號碼: E1449
| 產品號碼 | E1449 |
| 純度/分析方法 | >95.0%(T) |
| 分子式 / 分子量 | C__2__4H__2__1F__2NO__3 = 409.43 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 163222-33-1 |
| Reaxys-RN | 7981967 |
| PubChem Substance ID | 468591792 |
| MDL編號 | MFCD00937872 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 162.0 to 166.0 °C |
| Specific rotation | -20.0 to -30.0 deg(C=3, Methanol) |
| NMR | confirm to structure |
性質
| 熔點 | 163 °C |
| Maximum Wavelength | 285(CH3CN) nm |
| 水溶性 | Insoluble |
| Degree of solubility in water | 4.4 mg/l 25 °C |
| 溶解性（可溶於） | Ethanol, Methanol |
GHS
相關法規
| RTECS # | CM4554000 |
運輸資料
| HS編碼* | 2933.79-000 |
Application
Ezetimibe: A Potent Inhibitor of Cholesterol Intestinal Absorption
Ezetimibe (SCH 58235) is in a class of lipid-lowering agents that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. It has been reported that ezetimibe reduces the small intestinal enterocyte uptake and absorption of cholesterol by binding to a cholesterol transporter Niemann-Pick C1-Like 1 (NPC1L1) which is involved in the intestinal uptake of cholesterol and phytosterols, and keeps cholesterol in the intestinal lumen for excretion. (The product is for research purpose only.)
References
- Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
- The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
- Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport (a review)
- Zetia: inhibition of Niemann-Pick C1 like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia (a review)
- Development and validation of a reversed-phase HPLC method for the determination of ezetimibe in pharmaceutical dosage forms
- Stress degradation studies on ezetimibe and development of a validated stability-indicating HPLC assay
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