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CAS RN: 77-67-8 | 產品號碼: E0746
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 48.0 to 52.0 °C |
性質
| 熔點 | 51 °C |
| 沸點 | 150 °C/12 mmHg |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | WN2800000 |
運輸資料
| HS編碼* | 2925.19-000 |
Application
Ethosuximide: A Specific T-Type Ca2+ Channel Inhibitor
Ethosuximide is a specific T-type Ca2+ channel inhibitor, and is presumed to reduce these low threshold T-type Ca2+ currents in thalamic neurons. Ethosuximide prevents the burst activity of thalamic neurons that is required for synchronous activation of cerebral cortical cells. Meanwhile, ethosuximide does not have any effect on GABA-mediated inhibition. Ethosuximide is effective only in absence seizures, a symptom of epilepsy. (The product is for research purpose only.)
References
- Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons
- Effects of ethosuximide, a T-type Ca2+channel blocker, on dorsal horn neuronal responses in rats
- Ethosuximide: from bench to bedside (a review)
- Ethosuximide (a review)
- Liquid-chromatographic determination of six antiepileptic drugs and two metabolites in microsamples of human plasma
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