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CAS RN: 562-10-7 | 產品號碼: D5583
Doxylamine Succinate
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產品號碼 | D5583 |
純度/分析方法 | >98.0%(T)(HPLC) |
分子式 / 分子量 | C__1__7H__2__2N__2O·C__4H__6O__4 = 388.46 |
外觀與形狀(20°C) | Solid |
儲存條件 | Frozen (<0°C) |
應避免的情況 | Light Sensitive,Heat Sensitive |
CAS RN | 562-10-7 |
相關CAS RN | 469-21-6 |
PubChem Substance ID | 468591428 |
Merck Index(14) | 3441 |
MDL編號 | MFCD00056168 |
產品規格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 %(total of Ion-Pair) |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 109.0 to 113.0 °C |
NMR | confirm to structure |
性質
熔點 | 111 °C |
溶解性(可溶於) | Alcohol, Chloroform |
溶解性(微溶於) | Benzene, Ether |
GHS
圖形表示 | |
信號詞 | Warning |
危險性說明 | H302 : Harmful if swallowed. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
RTECS # | US9275000 |
運輸資料
HS編碼* | 2933.39-000 |
Application
Doxylamine Succinate: A First-Generation Anti-Histamine
Doxylamine succinate is a first-generation anti-histamine similar in structure to diphenhydramine [D4744]. Because of its sedative effect, it is often used for the treatment of insomnia and nausea in clinical use. (The product is for research purpose only.)
References
- Doxylamine succinate-pyridoxine hydrochloride (Diclegis) for the management of nausea and vomiting in pregnancy: an overview (a review)
- Simultaneous determination of pyridoxine hydrochloride and doxylamine succinate from tablets by ion pair reversed-phase high-performance liquid chromatography (RP-HPLC)
- Determination of the sleep aid ingredients diphenhydramine hydrochloride and doxylamine succinate in pharmaceutical products by quantitative HPTLC
- Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: Application to a pharmacokinetic study
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