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CAS RN: 878143-33-0 | 產品號碼: D5481
Dolasetron Mesylate Monohydrate
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| 產品號碼 | D5481 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__9H__2__0N__2O__3·CH__4O__3S·H__2O = 438.50 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 878143-33-0 |
| 相關CAS RN | 115956-13-3 |
| Reaxys-RN | 8461425 |
| PubChem Substance ID | 468591363 |
| Merck Index(14) | 3411 |
| MDL編號 | MFCD01718979 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 6.10 to 6.70 % |
| Water | 3.0 to 5.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 178 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | NL6015300 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Dolasetron Mesylate: A Selective Serotonin Subtype 3 (5-HT3) Receptor Antagonist
Dolasetron mesylate is a selective serotonin subtype 3 (5-HT3) receptor antagonist. It is rapidly converted in vivo to its active major metabolite, hydrodolasetron, which appears to be largely responsible for its pharmacological activity. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, selective 5-HT3 receptor antagonists, dolasetron, granisetron [G0401], ondansetron [O0407] and tropisetron [T2743] are used for the prevention of chemotherapy-induced nausea and vomiting, but they have been reported to be associated with QTc prolongation. (The product is for research purpose only.)
References
- Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma × glioma cells
- Dolasetron: a review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery (a review)
- Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels
- Other drugs acting on nervous system associated with QT-interval prolongation (a review)
- Validation of a reversed-phase HPLC method for directly quantifying the enantiomers of MDL 74,156, the primary metabolite of dolasetron mesylate, in human plasma.
- Optimization of Sample Pretreatment Methods for Simultaneous Determination of Dolasetron and Hydrodolasetron in Human Plasma by HPLC-ESI-MS
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