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CAS RN: 146535-11-7 | 產品號碼: D4601
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 138.0 to 142.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 140 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.99-000 |
Application
AG-1296: A Platelet-Derived Growth Factor Receptor (PDGFR) Kinase Inhibitor
AG-1296 is reported to inhibit selectively the platelet-derived growth factor (PDGF) receptor kinase and the PDGF-dependent DNA synthesis.
References
- Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation
- Phosphorylation Site-Specific Inhibition of Platelet-Derived Growth Factor β-Receptor Autophosphorylation by the Receptor Blocking Tyrphostin AG1296
- PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine
- Tethering of the platelet-derived growth factor β receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells
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