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CAS RN: 23541-50-6 | 產品號碼: D4532
Daunorubicin Hydrochloride
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| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 20MG |
NT$4,920
|
8 | 11 |
| 100MG |
NT$17,160
|
20 | ≥100 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | D4532 |
| 純度/分析方法 | >98.0%(N) |
| 分子式 / 分子量 | C__2__7H__2__9NO__1__0·HCl = 563.98 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic,Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 20MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 23541-50-6 |
| 相關CAS RN | 20830-81-3 |
| Reaxys-RN | 4229221 |
| PubChem Substance ID | 253661912 |
| Merck Index(14) | 2832 |
| MDL編號 | MFCD04974507 |
產品規格
| Appearance | Orange to Red powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | +250 to +275 deg(C=0.15, MeOH) |
| Drying loss | max. 7.5 % |
性質
| 熔點 | 167 °C(dec.) |
| 比旋光 [α]D | 260° (C=0.15,MeOH) |
| Maximum Wavelength | 477(H2O) nm |
| 水溶性 | Soluble |
| 溶解性（可溶於） | Methanol |
| 溶解性（不溶於） | Ether, Chloroform, Benzene |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H341 : Suspected of causing genetic defects. H351 : Suspected of causing cancer. H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P273 : Avoid release to the environment. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | HB7878000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2941.90-000 |
Application
Adeno-associated virus vector transduction enhancer
Daunorubicin exhibits enhancement of adeno-associated virus transduction.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
Application
Daunorubicin Hydrochloride: An Anthracycline Antitumor Antibiotic
Daunorubicin Hydrochloride, an anthracycline antitumor antibiotic, was first isolated from fermentation broths of Streptomyces peucetius in 1967. Daunorubicin interacts with DNA by intercalation that causes disruption of transcription and replication. Daunorubicin also forms a complex with DNA and the enzyme topoisomerase II which is essential enzyme for DNA replication. The complexation hinders religation and leads to tumor cell apoptosis. Daunorubicin is mainly used for acute myeloid leukemia. (The product is for research purpose only.)
References
- Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals
- Biosynthetic studies of daunorubicin and tetracenomycin C (a review)
- A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicin (a review)
- Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity (a review)
- DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs (a review)
考研文獻
文章/手冊
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