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CAS RN: 520-34-3 | 產品號碼: D4441
產品規格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 260.0 to 264.0 °C |
性質
| 熔點 | 262 °C |
| Maximum Wavelength | 348(MeOH) nm |
| 溶解性（可溶於） | Acetone, Chloroform, dichloromethane |
GHS
相關法規
| RTECS # | DJ2984400 |
運輸資料
| HS編碼* | 2932.99-000 |
Application
Diosmetin: A Flavonoid with Diverse Biological Activities
Diosmetin, the aglycon part of diosmin [D3908], is a flavonoid that has been found in citrus fruits. It has been reported to exert diverse biological activities such as anti-oxidative, anti-inflammatory, anti-apoptotic, and anti-tumor activities.1-4) In addition, it inhibits the cytochrome P450 isoforms CYPA1 and CYP1B1.5) (The product is for research purpose only.)
References
- 1) Intracellular Antioxidant Detoxifying Effects of Diosmetin on 2,2-Azobis(2-amidinopropane) Dihydrochloride (AAPH)-Induced Oxidative Stress through Inhibition of Reactive Oxygen Species Generation
- 2) Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
- 3) A review on pharmacological and analytical aspects of diosmetin: A concise report
- 4) Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer
- 5) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids
- 6) Simultaneous determination of diosmin and diosmetin in human plasma by ion trap liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: Application to a clinical pharmacokinetic study
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