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CAS RN: 251456-60-7 | 產品號碼: D4188
4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
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![4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide")
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| 產品號碼 | D4188 |
| 純度/分析方法 | >97.0%(HPLC) |
| 分子式 / 分子量 | C__1__6H__2__5N__3O__3 = 307.39 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 20MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 251456-60-7 |
| Reaxys-RN | 8570090 |
| PubChem Substance ID | 160871269 |
| MDL編號 | MFCD03453554 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Elemental analysis(Nitrogen) | 13.20 to 13.80 % |
| NMR | confirm to structure |
性質
| 熔點 | 152 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2928.00-000 |
Application
M344: A Histone Deacetylase (HDAC) Inhibitor
Histone deacetylase (HDAC) inhibitors are emerging therapeutic agents with potential for disruption of critical cellular processes in cancer cells. M344 is a synthesized HDAC inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in cancer cells. (The product is for research purpose only.)
References
- Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
- Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation
- The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells
- M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells
- Histone deacetylase inhibitor M344 inhibits cell proliferation and induces apoptosis in human THP-1 leukemia cells
- Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB
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