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CAS RN: 555-30-6 | 產品號碼: D1817
3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine Sesquihydrate
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| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 5G |
NT$2,920
|
24 | 5 |
| 25G |
NT$8,560
|
20 | 聯繫我們 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
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| 產品號碼 | D1817 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__0H__1__3NO__4·1^^1/__2H__2O = 238.24 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Air Sensitive |
| CAS RN | 555-30-6 |
| 相關CAS RN | 41372-08-1 |
| Reaxys-RN | 2807721 |
| PubChem Substance ID | 87568286 |
| Merck Index(14) | 6055 |
| MDL編號 | MFCD00004186 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | -12.5 to -14.5 deg(C=1, H2O) |
| Solubility in hot Water | almost transparency |
| Water | 10.0 to 12.0 % |
| NMR | confirm to structure |
性質
| 比旋光 [α]D | -14° (C=1,H2O) |
GHS
相關法規
| RTECS # | AY5950000 |
運輸資料
| HS編碼* | 2922.50-000 |
Application
Methyldopa: An Aromatic-Amino Acid Decarboxylase Inhibitor
Methyldopa is an aromatic-amino acid decarboxylase inhibitor. It inhibits the decarboxylation of L-DOPA [D0600], thereby interfering with the formation of dopamine [A0305 (HCl salt)], a precursor of L-norepinephrine [A0906 (bitartrate)]. Methyldopa is an effective anti-hypertensive agent that reduces both supine and standing blood pressure. At first, the anti-hypertensive activity was believed to be related with the inhibition. Nowadays, methyldopa is metabolized to α-methylnorepinephrine and this compound is thought to stimulate central nerve α-adrenergic receptors, producing a decrease in peripheral sympathetic outflow, and resulting in decreasing blood pressure. (The product is for research purpose only.)
References
- Studies on the metabolism and mechanism of action of methyldopa
- α-Sympathetic receptor stimulation in the brain and hypotensive activity of α-methyldopa
- Clinical pharmacokinetics of methyldopa (a review)
- Spectrophotometric determination of methyldopa in pure and pharmaceutical preparations
- Simultaneous determination of serum concentrations of levodopa, dopamine, 3-O-methyldopa and α-methyldopa by HPLC
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