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CAS RN: 302964-08-5 | 產品號碼: C3675
2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
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![2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide")
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| 產品號碼 | C3675 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__6H__1__3Cl__2N__5OS = 394.27 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 302964-08-5 |
| Reaxys-RN | 9869700 |
| PubChem Substance ID | 468591222 |
| MDL編號 | MFCD11045075 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 280 °C |
| Maximum Wavelength | 320 nm (MeOH) |
GHS
相關法規
運輸資料
| HS編碼* | 2934.10-000 |
Application
A Key Synthetic Intermediate of Dasatinib
This product is a key synthetic intermediate of dasatinib (BMS-354825) which is a dual BCR/ABL and Src family tyrosine kinase inhibitor used for the treatment of chronic myelogenous leukemia (CML).
References
- Discovery of N-(2-Chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent AntitumorActivity in Preclinical Assays
- 2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure-Activity Relationship Studies toward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent pan-Src Kinase Inhibitor
- Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes
- Trace level determination and quantification of potential genotoxic impurities in dasatinib drug substance by UHPLC/infinity LC
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