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CAS RN: 117048-59-6 | 產品號碼: C2520
Combretastatin A4
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| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 250MG |
NT$29,400
|
8 | 1 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
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產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
性質
| 熔點 | 83 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2909.50-000 |
Application
Combretastatin A4: Antimitotic Agent
Combretastatin A4 (CA-4), isolated from the African bush willow (Combretum caffrum), binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. Concequentry, CA-4 shows strong cytotoxicity against a variety of tumor cells. Recently, various CA-4 analogs have been synthesized and evaluated for antitumor activity.
References
- Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
- Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
- G. G. Dark, S. A. Hill, V. E. Prise, G. M. Tozer, G. R. Pettit, D. J. Chaplin, Cancer Res. 1997, 57, 1829.
- Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues
- G. M. Tozer, V. E. Prise, J. Wilson, R. J. Locke, B. Vojnovic, M. R. L. Stratford, M. F. Dennis, D. J. Chaplin, Cancer Res. 1999, 59, 1626.
- Medicinal chemistry of combretastatin A4: Present and future directions
- Combretastatin A-4 analogs as anticancer agents
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