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CAS RN: 104376-79-6 | 產品號碼: C2226
Ceftriaxone Disodium Salt Hemiheptahydrate
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This product has not been tested for potency and is guaranteed for chemical purity.
| 產品號碼 | C2226 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__8H__1__6N__8Na__2O__7S__3·3^^1/__2H__2O = 661.58 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 應避免的情況 | Light Sensitive |
| CAS RN | 104376-79-6 |
| 相關CAS RN | 73384-59-5&74578-69-1 |
| Reaxys-RN | 9110623 |
| PubChem Substance ID | 87560125 |
| MDL編號 | MFCD00941454 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -150 to -170 deg(C=1, H2O)(calcd.on anh.substance) |
| Water | 8.0 to 11.0 % |
性質
| 熔點 | 236 °C |
| 比旋光 [α]D | -160° (C=1,H2O) |
| 水溶性 | Soluble |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
相關法規
| RTECS # | XI0368800 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Ceftriaxone Disodium: A Third Generation Semisynthetic Cephalosporin Antibiotic with Longer Serum Half-Life
Ceftriaxone disodium salt is a third generation semisynthetic cephalosporin antibiotic, which is chemically synthesized form 7-aminocephalosporanic acid (7-ACA) [A1266]. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the first and second generation cephalosporins. It has increased stability to β-lactamases compared with the first and second generation cephalosporins. Incorporation of the triazine substituted side chain into the 3-position of the cephalosporin nucleus markedly prolong serum half-life.
References
- Ceftriaxone: a review of its antibacterial activity, pharmacological properties and therapeutic use
- Ceftizoxime and other third-generation cephalosporins: structure-activity relationships
- Ceftriaxone: a beta-lactamase-stable, broad-spectrum cephalosporin with an extended half-life
- Ceftriaxone (an update of its use in the management of community-acquired and nosocomial infections)
- Solubility and Density of the Disodium Salt Hemiheptahydrate of Ceftriaxone in Water + Ethanol Mixtures
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