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CAS RN: 303-26-4 | 產品號碼: C1611
1-(4-Chlorobenzhydryl)piperazine
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| 產品號碼 | C1611 |
| 純度/分析方法 | >98.0%(GC) |
| 分子式 / 分子量 | C__1__7H__1__9ClN__2 = 286.80 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 303-26-4 |
| Reaxys-RN | 243027 |
| PubChem Substance ID | 87566606 |
| MDL編號 | MFCD00005965 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 72.0 to 76.0 °C |
性質
| 熔點 | 75 °C |
| 沸點 | 180 °C/0.8 mmHg |
| 溶解性（可溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | TL1772000 |
運輸資料
| HS編碼* | 2933.59-000 |
Application
A Key Synthetic Intermediate of Cetirizine Dihydrochloride
This product has been used as a key synthetic intermediate of cetirizine dihydrochloride [C2316] which is a second-generation histamine H1-receptor antagonist.
References
- Synthesis of piperazine derivatives and evaluation of their antihistamine and antibradykinin effects
- Development and validation of a heart-cutting liquid chromatography-mass spectrometry method for the determination of process-related substances in cetirizine tablets
- Determination of levocetirizine configurational stability in tablets using chiral HPLC method
考研文獻
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