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CAS RN: 96187-53-0 | 產品號碼: B5707
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 3.50 to 4.00 % |
性質
| 熔點 | 317 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.49-000 |
Application
Brequinar: An Inhibitor of Dihydroorotate Dehydrogenase (DHODH)
Brequinar is a synthetic quinolinecarboxylic acid analogue with antineoplastic and immunosuppressive properties. Brequinar reportedly inhibits the enzyme dihydroorotate dehydrogenase (DHODH) which is catalyzes the conversion of dihydroorotate (DHO) to orotate, the fourth reaction of pyrimidine de novo synthesis. (The product is for research purpose only.)
References
- Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives
- Multiple Inhibitor Analysis of the Brequinar and Leflunomide Binding Sites on Human Dihydroorotate Dehydrogenase
- Characterization of dengue virus resistance to brequinar in cell culture
- Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors (a review)
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