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CAS RN: 603-50-9 | 產品號碼: B5066
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 132.0 to 136.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 134 °C |
| Maximum Wavelength | 220(MeOH) nm |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | SM8750000 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Bisacodyl: A Diphenylmethane Stimulant Laxative
Bisacodyl is used as a diphenylmethane stimulant laxative. Bisacodyl is hydrolyzed by intestinal brush border enzymes and colonic bacteria to form an active metabolite bis(p-hydroxyphenyl)-2-pyridylmethane that acts directly on the colonic mucosa to produce colonic peristalsis. (The product is for research purpose only.)
References
- Entacetylierung und Resorption von phenolischen Laxantien
- Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate.
- Aspects of the pharmacology of diphenylmethane laxatives (bisacodyl, oxyphenisatin and phenolphthalein derivatives) (a review)
- R. B. Sund, Norvegica Pharm. Acta 1983, 45, 125.
- Nitric oxide as a mediator of bisacodyl and phenolphthalein laxative action: induction of nitric oxide synthase
- High-performance liquid chromatographic determination of bisacodyl in pharmaceutical dosage forms marketed in Australia
考研文獻
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