Maximum quantity allowed is 999
请选择数量
CAS RN: 380843-75-4 | 產品號碼: B4824
Bosutinib
×
![]()
×
纯度/分析方法: >95.0%(T)(HPLC)
別名
- SKI-606
- 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
- 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
文件：
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | B4824 |
| 純度/分析方法 | >95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__6H__2__9Cl__2N__5O__3 = 530.45 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic |
| 包裝和容器 | 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 380843-75-4 |
| Reaxys-RN | 9100307 |
| MDL編號 | MFCD07367846 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Water | max. 5.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 120 °C |
| 水溶性 | Insoluble |
| Degree of solubility in water | 7 mg/l 25 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H320 : Causes eye irritation. H317 : May cause an allergic skin reaction. H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P273 : Avoid release to the environment. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | VB0990000 |
運輸資料
| HS編碼* | 2933.59-000 |
Application
Bosutinib: A Potent ATP-Competitive Tyrosine Kinase Inhibitor
Bosutinib (SKI-606) is a potent ATP-competitive tyrosine kinase inhibitor. Bosutinib has been reported to inhibit the Bcr-Abl kinase, which promotes chronic myeloid leukemia (CML). Inhibition of Bcr-Abl tyrosine kinase activity or signaling proteins activated by Bcr-Abl in CML cells blocks proliferation and causes apoptotic cell death. Bosutinib is also inhibits the phosphorylation of cellular signaling proteins, including Src-family kinases (Src, Lyn, and Hck) and STAT5. (The product is for research purpose only.)
References
- SKI-606, a 4-Anilino-3-quinolinecarbonitrile Dual Inhibitor of Src and Abl Kinases, Is a Potent Antiproliferative Agent against Chronic Myelogenous Leukemia Cells in Culture and Causes Regression of K562 Xenografts in Nude Mice
- In vitro and in vivo Activity of SKI-606, a Novel Src-Abl Inhibitor, against Imatinib-Resistant Bcr-Abl+ Neoplastic Cells
- Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
- Bosutinib: A Potent Second-Generation Tyrosine Kinase Inhibitor (a review)
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。