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CAS RN: 5534-09-8 | 產品號碼: B4464
Beclometasone Dipropionate
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| 產品號碼 | B4464 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__8H__3__7ClO__7 = 521.05 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 5534-09-8 |
| Reaxys-RN | 3638107 |
| PubChem Substance ID | 253662548 |
| Merck Index(14) | 1019 |
| MDL編號 | MFCD00135613 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +88.0 to +94.0 deg(C=1, Dioxane) |
性質
| 熔點 | 208 °C(dec.) |
| 比旋光 [α]D | 90° (C=1,Dioxane) |
| Maximum Wavelength | 238(EtOH) nm |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | TU3805000 |
運輸資料
| HS編碼* | 2937.29-000 |
Application
Beclomethasone Dipropionate: A Prodrug with Weak Glucocorticoid Receptor Binding Affinity
Beclomethasone dipropionate (BDP), a synthetic ant-inflammatory glucocorticoid and corticosteroid, is a prodrug with weak glucocorticoid receptor binding affinity. BDP is hydrolyzed with esterase enzymes to an active metabolite beclomethasone 17-monopropionate and minor inactive metabolites, beclomethasone 21-monopropionate and beclomethasone. BDP is freely soluble in acetone and ethanol, soluble in chloroform, and very slightly soluble in water. BDP is used for treatment of asthma and rhinitis. (The product is for research purpose only.)
References
- Beclomethasone dipropionate. A reappraisal of its pharmacodynamic properties and therapeutic efficacy after a decade of use in asthma and rhinitis (a review)
- Review of the toxicology of beclomethasone dipropionate
- Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man
- Sensitive liquid chromatographic/tandem mass spectrometric method for the determination of beclomethasone dipropionate and its metabolites in equine plasma and urine
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