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CAS RN: 484-20-8 | 產品號碼: B2840
Bergapten
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| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 1G |
NT$4,000
|
11 | 19 |
| 5G |
NT$14,520
|
2 | 聯繫我們 |
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洽詢。
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| 產品號碼 | B2840 |
| 純度/分析方法 | >98.0%(GC) |
| 分子式 / 分子量 | C__1__2H__8O__4 = 216.19 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 應避免的情況 | Light Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 484-20-8 |
| Reaxys-RN | 19560 |
| PubChem Substance ID | 87558737 |
| Merck Index(14) | 1157 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 189.0 to 193.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 191 °C |
| Maximum Wavelength | 480(MeOH) nm |
| 溶解性（可溶於） | Ether |
| 溶解性（微溶於） | Alcohol, Benzene, Chloroform |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H317 : May cause an allergic skin reaction. H350 : May cause cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | LV1300000 |
運輸資料
| HS編碼* | 2932.99-000 |
Application
5-Methoxypsoralen (5-MOP): A Photosensitizer in Combination with UV-A irradiation, called PUVA
5-Methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP) [X0009] and 4,5',8-trimethylpsoralen [T2267] are naturally occurring linear psoralens (furocoumarins). They have been successfully used as photosensitizers in combination with UV-A irradiation which is called the psoralen-based PUVA (psoralen + UV-A) to manage dermatological diseases, such as psoriasis, vitiligo and cancer. Reportedly, the most important mechanism implies the [2 + 2] cycloaddition photoreaction of psoralen and a DNA pyrimidine nucleobase. The formation of psoralen-pyrimidine adducts prevents the division of the injured cells. In another photoreaction, the activated psoralen can transfer energy to molecular oxygen to generate reactive radicals or excited singlet oxygen which becomes prone to damage the membrane of the harmed cell. In addition, 5-MOP and 8-MOP work as Cytochrome P450 inhibitors. (The product is for research purpose only.)
References
- The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD (a review)
- 5-Methoxypsoralen: a review of its effects in psoriasis and vitiligo (a review)
- Photoreactivity of Furocoumarins and DNA in PUVA Therapy: Formation of Psoralen－Thymine Adducts
- Mechanism-Based Inactivation of Cytochrome P450 2B1 by 8-Methoxypsoralen and Several Other Furanocoumarins
考研文獻
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