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CAS RN: 379231-04-6 | 產品號碼: A3611
Saracatinib
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纯度/分析方法: >95.0%(HPLC)(qNMR)
別名
- AZD0530
- N-[5-Chlorobenzo[d][1,3]dioxol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]quinazolin-4-amine
- N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)-4-quinazolinamine
文件：
| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 25MG |
NT$6,000
|
18 | 聯繫我們 |
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| 產品號碼 | A3611 |
| 純度/分析方法 | >95.0%(HPLC)(qNMR) |
| 分子式 / 分子量 | C__2__7H__3__2ClN__5O__5 = 542.03 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 379231-04-6 |
| Reaxys-RN | 10742554 |
| MDL編號 | MFCD09832698 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 144 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
Saracatinib: A Highly Selective Dual Inhibitor of c-Src and Abl Tyrosine Kinases
Saracatinib (AZD0530) is an oral, highly selective dual inhibitor of c-Src and Abl tyrosine kinases.1-3) Saracatinib has been shown to inhibit tumor growth in a c-Src-transfected 3T3 fibroblast xenograft model in vivo.1) However, while saracatinib was well tolerated in humans, there were no responses and it did not show sufficient efficacy in cancer patients.4) More recently, saracatinib has been investigated in other indications, including Alzheimer's disease.5) (The product is for research purpose only.)
References
- 1) N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor
- 2) Novel dual Src/Abl inhibitors for hematologic and solid malignancies
- 3) Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors (a review)
- 4) Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer
- 5) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice
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