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CAS RN: 84692-91-1 | 產品號碼: A3449
Arglabin
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 5MG |
NT$14,960
|
8 | 2 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
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產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +101 to +104 deg (C=0.3, CHCl3) |
| NMR | confirm to structure |
性質
| 熔點 | 102 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2932.20-000 |
Application
Arglabin: A Natural NLRP3 Inhibitor
Arglabin, a sesquiterpene γ-lactone, is originally extracted from Artemisia glabella, and also is found in Artemisia myiantha (a species of wormwood) which is a plant commonly used in traditional Chinese medicine.1,2) Arglabin and its derivatives have been reported as NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome inhibitors which show anti-inflammatory antitumor, and antiviral (including anti-SARS-CoV-2) activities.2-5) The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene.2) (The product is for research purpose only.)
References
- 1) In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall. (Asteraceae).
- 2) Arglabin: From isolation to antitumor evaluation (a review)
- 3) Sesquiterpene lactones from Artemisia Genus: biological activities and methods of analysis (a review)
- 4) Chemical modification of arglabin and biological activity of its new derivatives (a review)
- 5) Targeting the NLRP3 inflammasome in severe COVID-19 (a review)
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