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CAS RN: 199875-69-9 | 產品號碼: A3446
N-Arachidonoyl Dopamine
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| 產品號碼 | A3446 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__8H__4__1NO__3 = 439.64 |
| 外觀與形狀（20°C） | Liquid |
| 儲存條件 | Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 199875-69-9 |
| Reaxys-RN | 7779367 |
| MDL編號 | MFCD03412031 |
產品規格
| Appearance | Colorless to Yellow clear liquid |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| NMR | confirm to structure |
性質
| flp | 341 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2924.19-000 |
Application
N-Arachidonoyldopamine: An Endogenous Cannabinoid
N-Arachidonoyldopamine (NADA) is was first synthesized as a pharmacological tool to study the endogenous cannabinoid system (ECS).1) Later NADA and other N-acyldopamines were identified as endogenous cannabinoids in the mammalian nervous tissue.2,3) It has been reported that NADA acts as an agonist of the cannabinoid 1 (CB1) receptors.1-3) It is selective for CB1 over CB2 receptors. Furthermore, NADA also acts as an agonist of the transient receptor potential vanilloid type 1 (TRPV1) ion channel, also known as the capsaicin receptor.2,3) For your reference, the endogenous cannabinoid system (ECS) modulates neuronal and immune cell function, both of which play key roles in pain, therapeutics targeting this system hold promise as novel analgesics.3) (The product is for research purpose only.)
References
- 1) N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
- 2) An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
- 3) N-arachidonoyl dopamine: a novel endocannabinoid and endovanilloid with widespread physiological and pharmacological activities (a review)
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