Maximum quantity allowed is 999
请选择数量
CAS RN: 909910-43-6 | 產品號碼: A3324
A 83-01
×
![]()
×
| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 25MG |
NT$14,920
|
1 | 0 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
產品規格
| Appearance | White to Orange to Green powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
性質
GHS
相關法規
運輸資料
| HS編碼* | 2933.49-000 |
Application
A Thioamide for the Potent Inhibition of TGF-β Signaling
Reference
- The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β
- TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion
- Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
Application
A 83-01: A Potent Inhibitor of Activin Receptor-Like Kinase 4/5/7 (ALK4/5/7)
Transforming growth factor (TGF)-β signaling facilitates tumor growth and metastasis in advanced cancer. A 83-01 has been reported to be an inhibitor of TGF-β type I receptor kinase (ALK5), activing type IB receptor (ALK4), and nodal type I receptor (ALK7), respectively.1) Furthermore, A 83-01 has been used to reprogram fibroblasts into alternative lineages, such as cardiomyocyte-like cells.2) Therefor, A 83-01 is thought to affect stem cell differentiation and tumor progression in animal models.3)
References
- 1) The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β
- 2) Conversion of human fibroblasts into functional cardiomyocytes by small molecules
- 3) Perspectives of small molecule inhibitors of activin receptor.like kinase in anti.tumor treatment and stem cell differentiation (Review)
文章/手冊
TCIMail
[Product Highlights] A Thioamide for the Potent Inhibition of TGF-β Signaling[TCIMAIL No.193] Activin Receptor-Like Kinase (ALK) 4/5/7 Inhibitor
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。