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CAS RN: 181183-52-8 | 產品號碼: A3111
Almotriptan Malate
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| 產品號碼 | A3111 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__7H__2__5N__3O__2S·C__4H__6O__5 = 469.55 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 181183-52-8 |
| 相關CAS RN | 154323-57-6 |
| Reaxys-RN | 15435698 |
| PubChem Substance ID | 468590147 |
| Merck Index(14) | 304 |
| MDL編號 | MFCD08067740 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 8.50 to 9.50 % |
| NMR | confirm to structure |
性質
| 熔點 | 162 °C(dec.) |
| 水溶性 | Soluble |
GHS
相關法規
運輸資料
| HS編碼* | 2935.90-000 |
Application
Almotriptan Malate: A Selective 5-HT1B/1D Receptor Agonist
Almotriptan malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, known as triptan. Almotriptan binds with high affinity to 5-HT1B, 5-HT1D, and 5-HT1F receptors, and has weak affinity for 5-HT1A and 5-HT7 receptors. However, almotriptan has no significant affinity at 5-HT2, 5-HT3, 5-HT4 or 5-HT6. Triptans, including almotriptan, are major advance in the treatment of migraine. The therapeutic activity of triptans in migramine can most likely to be attributed to agonist effects at 5-HT1B/1D receptors on the intracranial blood vessels. (The product is for research purpose only.)
References
- Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine
- Almotriptan, a New Anti‐Migraine Agent: A Review
- Triptans in migraine: A comparative review of pharmacology, pharmacokinetics and efficacy
- A validated reversed phase HPLC method for the determination of process-related impurities in almotriptan malate active pharmaceutical ingredient
- A validated RP HPLC method for estimation of almotriptan malate in pharmaceutical dosage form
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