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CAS RN: 757251-39-1 | 產品號碼: A2979
4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide
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產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 141.0 to 145.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 143 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
A Key Synthetic Intermediate of Regorafenib
This product is used for a key synthetic intermediate of regorafenib [R0142] which is a multikinase inhibitor of tumour angiogenesis, oncogenesis and the tumour microenvironment.
References
- Fluoro substituted omega-carboxyaryl diphenyl urea for treatment of raf, VEGFR, PDGFR, p38 and flt-3 kinase-mediated diseases
- J. Dumas, S. Boyer, B. Riedl, S. Wilhelm, World Intellectual Property Organization, WO/2005/009961 A2.
- An efficient and high-yielding protocol for the production of Regorafenib via a new synthetic strategy
- A new pathway via intermediate 4-amino-3-fluorophenol for the synthesis of regorafenib
考研文獻
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產品規格
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