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CAS RN: 154229-19-3 | 產品號碼: A2868
Abiraterone
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| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 20MG |
NT$1,720
|
4 | 20 |
| 200MG |
NT$6,480
|
22 | ≥40 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
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洽詢。
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| 產品號碼 | A2868 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__4H__3__1NO = 349.52 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 200MG-Glass Bottle with Plastic Insert （閲覽圖片）, 20MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 154229-19-3 |
| Reaxys-RN | 7309269 |
| PubChem Substance ID | 253661112 |
| MDL編號 | MFCD00924100 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 226.0 to 230.0 °C |
| Specific rotation [a]20/D | -57.0 to -65.0 deg (C=0.5,CHCl3) |
性質
| 熔點 | 228 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
Abiraterone: A Selective Inhibitor of the Steroidogenic Enzyme Cytochrome P450 17A1 (CYP17A1)
Abiraterone is a selective inhibitor of the steroidogenic enzyme cytochrome P450 17A1 (CYP17A1) which catalyzes two key serial reactions (17α-hydroxylase hydroxylase and 17,20-lyase) in androgen and estrogen biosynthesis. Abiraterone acetate [A2891] (of which the active metabolite is abiraterone) is an agent used in combination with prednisone [P1276] in metastatic castration-resistant prostate cancer (mCRPC). (The product is for research purpose only.)
References
- The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P45017α by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3β-ol) and Related Steroidal Inhibitors
- Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate
- Resistance to CYP17A1 Inhibition with Abiraterone in Castration-Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants
- Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven (a review)
- CYP17 inhibitors-abiraterone, C17,20-lyase inhibitors and multi-targeting agents (a review)
考研文獻
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