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CAS RN: 71675-85-9 | 產品號碼: A2450
產品號碼 | A2450 |
純度/分析方法 | >98.0%(T)(HPLC) |
分子式 / 分子量 | C__1__7H__2__7N__3O__4S = 369.48 |
外觀與形狀(20°C) | Solid |
儲存條件 | Refrigerated (0-10°C) |
應避免的情況 | Heat Sensitive |
包裝和容器 | 100MG-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 71675-85-9 |
Reaxys-RN | 6876191 |
PubChem Substance ID | 135727298 |
Merck Index(14) | 485 |
MDL編號 | MFCD00866691 |
產品規格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 125.0 to 129.0 °C |
性質
熔點 | 127 °C |
GHS
圖形表示 |
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信號詞 | Warning |
危險性說明 | H302 : Harmful if swallowed. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
RTECS # | CV2308701 |
運輸資料
HS編碼* | 2933.99-000 |
Application
Amisulpride: A Selective Dopamine D2/D3 Receptors Antagonist
Amisulpride, a substituted benzamide derivative, is a selective dopamine D2/D3 receptors antagonist. Amisulpride binds selectively to dopaminergic D2 and D3 receptor subtypes without any affinity for D1, D4 and D5 receptor subtypes, in limbic system. Amisulpride is devoid of affinity for serotonin receptors or other neurogenic receptors such as histamine, cholinergic and adrenergic receptors. Recently, the amisulpride antagonism of 5-HT7 receptors has been reported. (The product is for research purpose only.)
References
- Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
- Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity
- Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality (a review)
- Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo
- Stereospecific determination of amisulpride, a new benzamide derivative, in human plasma and urine by automated solid-phase extraction and liquid chromatography on a chiral column. Application to pharmacokinetics
- Comparative validation of amisulpride determination in pharmaceuticals by several chromatographic, electrophoretic and spectrophotometric methods
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