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Copper-Catalyzed Cyclopropanation of α-Diazoketones to Norcaradienes
Reisman et al. have reported a copper-catalyzed intramolecular arene cyclopropanation of α-diazoketones to provide the norcaradienes. In the catalyst screening, relatively electron-poor Cu(II) salts, such as Cu(hfacac)2 and Cu(tfacac)2, gave good results. Furthermore, they have applied the cyclopropanation to an enantioselective total synthesis of diterpenoid (+)-salvileucalin B. Its cytotoxicity against A549 and HT-29 human adenocarcinoma cells has been reported.
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