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CAS RN: 524-12-9 | Product Number: W0015
Wedelolactone
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Purity: >98.0%(HPLC)
Synonyms:
- 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one
- 7-Methoxy-5,11,12-trihydroxycoumestan
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1MG |
NT$3,880
|
5 | 0 | It can be shipped in about 3-4 weeks after ordering | |
| 10MG |
NT$17,480
|
0 | 15 | It can be shipped in about 3-4 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
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in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | W0015 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__0O__7 = 314.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 524-12-9 |
| Reaxys Registry Number | 332398 |
| PubChem Substance ID | 468593123 |
| MDL Number | MFCD07778564 |
Specifications
| Appearance | White to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 315 °C |
| Maximum Absorption Wavelength | 350(MeOH) nm |
GHS
Related Laws:
| RTECS# | DF8078630 |
Transport Information:
| H.S.code* | 2932.20-000 |
Application
Wedelolactone: A Selective and Irreversible Kinase Inhibitor with Broad Range of Biological Activities
Wedelolactone is a natural coumestan originally isolated from herbal plants, including Eclipta alba and in Wedelia calendulacea.1) It has been reported that wedelolactone is a selective and irreversible kinase inhibitor with broad range of biological activities. For example, wedelolactone is a direct inhibitor of IKK complex that can suppress lipopolysaccharide(LPS)-induced caspase-11 expression,2) an antidote for snake venom,3,4) an inhibitor of topoisomerase IIα,5) and an inducer of caspase-dependent apoptosis in cancer cells.6) (The product is for research purpose only.)
References
- 1) Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea
- 2) Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex
- 3) Neutralization of lethal and myotoxic activities of South American rattlesnake venom by extracts and constituents of the plant Eclipta prostrata (Asteraceae)
- 4) Ability of wedelolactone, heparin, and para-bromophenacyl bromide to antagonize the myotoxic effects of two crotaline venoms and their PLA2 myotoxins
- 5) Inhibition of topoisomerase IIα: Novel function of wedelolactone
- 6) Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt
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