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CAS RN: 24356-66-9 | Product Number: V0098
Vidarabine Monohydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Ara-A Monohydrate
- Adenine 9-β-D-Arabinofuranoside Monohydrate
- 9-(β-D-Arabinofuranosyl)adenine Monohydrate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
NT$5,520
|
13 | 16 | It can be shipped in about 3-4 weeks after ordering | |
| 5G |
NT$17,600
|
11 | 4 | It can be shipped in about 3-4 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | V0098 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3N__5O__4·H__2O = 285.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 24356-66-9 |
| Related CAS RN | 5536-17-4 |
| Reaxys Registry Number | 93029 |
| PubChem Substance ID | 87560128 |
| Merck Index (14) | 9976 |
| MDL Number | MFCD00065471 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -2.0 to -4.0 deg(C=1, DMF) |
| Drying loss | 5.0 to 7.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 253 °C |
| Specific Rotation | -3° (C=1,DMF) |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | AU6200000 |
Transport Information:
| H.S.code* | 2940.00-000 |
Application
Vidarabine: An Arabinosyladenine with Ant-Virus and Anti-Cancer Activities
Vidarabine (arabinosyladenine, ara-A) is a synthetic purine nucleoside, and was first synthesized by Lee et al. in 1960. Vidarabine was originally intended as an anti-cancer agent, while the anti-viral activity against herpesvirus and vaccinia virus was reported by Rudder et al in 1965. And also the activity against varicella-zoster virus was reported by Miller et al. in 1968. Vidarabine had a broad-spectrum activity against DNA viruses but little activity against RNA viruses. Vidarabine is converted to the active form vidarabine triphosphate (ara-ATP) which inhibits viral DNA polymerase activity in vitro and in vivo. (The product is for research purpose only.)
References
- Potential Anticancer Agents.1 Xl. Synthesis of the β-Anomer of 9-(D-Arabinofuranosyl)-Adenine
- Inhibitory effect of some nucleosides on the growth of various human viruses in tissue culture.
- Antiviral activity of 9-beta-D-arabinofuranosyladenine. I. Cell culture studies.
- Inhibition of Herpesvirus DNA Synthesis by 9-β-D-Arabinofuranosyladenine in Cellular and Cell-Free Systems
- The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA)
- Vidarabine: a preliminary review of its pharmacological properties and therapeutic use
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