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CAS RN: 4525-65-9 | Product Number: T3121
2,4,6-Trichlorophenyl Formate
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Purity: >97.0%(HPLC)
Synonyms:
- Formic Acid 2,4,6-Trichlorophenyl Ester
Product Documents:
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| Product Number | T3121 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__7H__3Cl__3O__2 = 225.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 4525-65-9 |
| Reaxys Registry Number | 2524466 |
| PubChem Substance ID | 253661984 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Argentometric Titration) | min. 95.0 % |
| Melting point | 81.0 to 85.0 °C |
Properties (reference)
| Melting Point | 83 °C |
| Solubility (soluble in) | Toluene |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2915.13-000 |
Application
TCI Practical Example: Introduction of Carbonyl Group by Using Formic Acid 2,4,6-Trichlorophenyl Ester
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Used Chemicals
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Procedure
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A solution of 2-iodofluorene (500 mg, 1.71 mmol), 2,4,6-trichlorophenyl formate (579 mg, 2.57 mmol), palladium(II) acetate (38.4 mg, 0.171 mmol), Xantphos (198 mg, 0.342 mmol) and triethylamine (470 µL, 3.42 mmol) in toluene (10 mL) was stirred at room temperature for 24 hours. The solvent was removed under reduced pressure and the residue was washed with acetonitrile to give 1 as a pale yellow solid (462 mg, 69% yield).
A solution of 1 (460 mg, 1.18 mmol), triethylamine (330 µL, 2.36 mmol), DMAP (7.2 mg, 59 µmol) and morpholine (154 µL, 1.77 mmol) in THF (5 mL) was stirred at 45 °C for 20 hours. The reaction was quenched with water and the aqueous layer was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate:hexane = 0:100 - 50:50) to give 2 as a white solid (305 mg, 93% yield).
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Experimenter’s Comments
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The reaction mixture at the first step was monitored by TLC (hexane:ethyl acetate = 1:19, Rf = 0.34).
The reaction mixture at the second step was monitored by TLC (hexane:ethyl acetate = 1:1, Rf = 0.26).
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Analytical Data
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2,4,6-Trichlorophenyl 9H-Fluorene-2-carboxylate (1)
(9H-Fluoren-2-yl)(morpholino)methanone (2)1H NMR (400 MHz, CDCl3);
(1) δ 8.41 (s, 1H), 8.29 (d, J = 8.1 Hz, 1H), 7.94-7.88 (m, 2H), 7.62 (d, J = 6.2 Hz, 1H), 7.48–7.38 (m, 4H), 4.02 (s, 2H).
(2) δ 7.81 (d, J = 7.6 Hz, 2H), 7.62-7.56 (m, 2H), 7.43-7.32 (m, 3H), 3.94 (s, 2H), 3.72 (brs, 8H). -
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Lead Reference
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- Trichlorophenyl Formate: Highly Reactive and Easily Accessible Crystalline CO Surrogate for Palladium-Catalyzed Carbonylation of Aryl/Alkenyl Halides and Triflates.
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Other References
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- Pd-Catalyzed External-CO-Free Carbonylation: Preparation of 2,4,6-Trichlorophenyl 3,4-Dihydronaphthalene-2-Carboxylate
- Formic Acid Derivatives as Practical Carbon Monoxide Surrogates for Metal-Catalyzed Carbonylation Reactions
Application
A Practical Crystalline Carbon Monoxide Surrogate
Typical Procedure: [R1 = 2-naphthyl, X = Br, NR3 = NBu3]1): Pd(OAc)2 (33 mg, 0.15 mmol, 3 mol%), xantphos (168 mg, 0.29 mmol, 6 mol%), and 2-bromonaphthalene (1 g, 4.83 mmol) are added to a 50 mL flask. Then, a solution of NBu3 (2.3 mL, 9.7 mmol, 2.0 eq.) in toluene (5 mL) is added to the flask. The mixture is warmed to 100 °C and stirred for 5 min. 2,4,6-Trichlorophenyl formate (1.3 g, 5.8 mmol, 1.2 eq.) in toluene (9 mL) is added to the mixture over 3 h with a syringe pump. After additional stirring at 100 °C for 1 h, the mixture is cooled to rt and concentrated. The residue is purified by silica gel column chromatography (eluent: hexane/EtOAc = 100/1) to afford 2,4,6-trichlorophenyl 2-naphthoate (1.5 g, 4.3 mmol, 89% yield) as a white crystal.
References
- 1)T. Ueda, H. Konishi, K. Manabe, Org. Lett. 2012, 14, 5370.
- 2)H. Konishi, T. Ueda, K. Manabe, Org. Synth. 2014, 91, 39.
- 3)H. Konishi, K. Manabe, Synlett 2014, 25, 1971.
PubMed Literature
Articles/Brochures
TCIMAIL
[Research Articles] A Practical Crystalline Carbon Monoxide Surrogate[TCI Practical Example] Introduction of Carbonyl Group by Using 2,4,6-Trichlorophenyl Formate
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