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CAS RN: 128625-52-5 | Product Number: R0296

Reagents for Condensation Reactions (1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate) (HPMC encapsulated)


Purity:
Synonyms:
  • 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate ca. 0.25 mmol/capsule (HPMC encapsulated)
Product Documents:
10EACH
NT$2,200
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Supplemental Product Information:

Contents (per one capsule)

  • 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate : ca. 0.25 mmol

Directions for Use

  • Each capsule contains all reagents for a single use on 0.25 mmol scale condensation reaction (amide coupling reaction) between carboxylic acid and amine.
    Typical condition: 0.25 mmol of carboxylic acid and 1.25 equiv. of amines and 2.0 equiv. of base in DMF (0.25 M) at 30 °C.

Related Products

  • B1774 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate

Product Number R0296
Molecular Formula / Molecular Weight C__1__8H__2__8F__6N__6OP__2 = 520.40 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Condition to Avoid Heat Sensitive
CAS RN 128625-52-5
Specifications
Appearance White to Almost white capsule
Functionality test (conversion ratio) min. 95.0 %
Properties (reference)
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H317 : May cause an allergic skin reaction.
H410 : Very toxic to aquatic life with long lasting effects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust.
P273 : Avoid release to the environment.
P272 : Contaminated work clothing should not be allowed out of the workplace.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P391 : Collect spillage.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
Transport Information:
UN Number UN3077
Class 9
Packing Group III
H.S.code* 3822.19-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
TCI Practical Example: The Condensation Reaction Using a Capsule Reagent

TCI Practical Example: The Condensation Reaction Using a Capsule Reagent

Used Chemicals

Procedure

Reagents for condensation capsule (1H-benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate) (one capsule) was added to a solution of 4-bromobenzoic acid (40 mg, 0.20 mmol, 1.0 eq.) and morpholine (17 μL, 0.20 mmol, 1.25 eq.) in DMF (1 mL) at room temperature and the mixture was stirred for 2 hours. The reaction solution was diluted with ethyl acetate (5 mL) and filtered through Celite. The organic layer was washed with 1 mol/L HCl aq. (5 mL), sat. NaHCO3 aq. (5 mL) and brine (20 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (hexane: ethyl acetate = 1:1 - 1:2) to afford (4-bromophenyl)(morpholino)methanone (65 mg, 97% yield) as a white solid.

Experimenter’s Comments

The reaction mixture was monitored by UPLC.
The shape of the capsule is like below image and each capsule includes 1H-benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate (ca. 0.25 mmol).
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).

カプセル

Analytical Data

(4-Bromophenyl)(morpholino)methanone

1H NMR (400 MHz, CDCl3); δ 7.57 (d, J = 8.4 Hz, 2H), 7.30 (d, J = 8.4 Hz, 2H), 3.74-3.44 (m, 8H).

Lead Reference

Other Reference


TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
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Other Documents

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