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CAS RN: 29745-04-8 | Product Number: N0914
Norcantharidin
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Purity: >98.0%(GC)(T)
Synonyms:
- exo-3,6-Epoxyhexahydrophthalic Anhydride
- exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Anhydride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
NT$2,600
|
1 | 1 | It can be shipped in about 2 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | N0914 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__8H__8O__4 = 168.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 29745-04-8 |
| Reaxys Registry Number | 84287 |
| PubChem Substance ID | 253659717 |
| MDL Number | MFCD00213361 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Methanolysis Method) | min. 98.0 % |
| Melting point | 113.0 to 117.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 115 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | RN8400000 |
Transport Information:
| H.S.code* | 2932.19-000 |
Application
抗腫瘍・抗転移作用を有するタンパク質ホスファターゼ阻害剤，ノルカンタリジン
Norcantharidin (NCTD) is the demethylated analog of a natural terpene, cantharidin [C0019]. NCTD has more powerful antitumor activity but less cytotoxicity than cantharidin itself. NCTD is a protein phosphatase inhibitor that induces cell cycle arrest and apoptosis, and also blocks tumor metastasis in cancer cells. (The product is for research purpose only.)
References
- Effects of norcantharidin, a protein phosphatase type-2A inhibitor, on the growth of normal and malignant hemopoietic cells
- Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells
- Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio
- Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity
- Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells
- Exploiting protein phosphatase inhibitors based on cantharidin analogues for cancer drug discovery (a review)
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