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CAS RN: 75706-12-6 | Product Number: L0250
Leflunomide
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 5-Methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 200MG |
NT$2,960
|
17 | 33 |
| 1G |
NT$9,280
|
1 | 3 |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | L0250 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__2H__9F__3N__2O__2 = 270.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 75706-12-6 |
| Reaxys Registry Number | 4323174 |
| PubChem Substance ID | 160871382 |
| Merck Index (14) | 5432 |
| MDL Number | MFCD00867593 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 166.0 to 170.0 °C |
Properties (reference)
| Melting Point | 168 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 27 mg/l 25 °C |
| Solubility (soluble in) | Acetone, Ethanol, Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | NY2354200 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2934.99-000 |
Application
Leflunomide: A Prodrug of Immunoregulatory Agent, Teriflunomide
Leflunomide is a prodrug of teriflunomide [T3287] which has two activites: inhibition of pyrimidine nucleotide synthesis and interference with tyrosine phosphorylation. More specifically, it inhibits the enzymic activity of dihydroorotate dehydrogenase (DHO-DHase) which catalyzes the fourth step in the biosynthesis of pyrimidine, and tyrosine kinases which transfer a phosphate group from ATP to a protein in a cell. Leflunomide reduces the proliferation of T and B immune cells that are active in multiple sclerosis (MS). For your reference, [C3217] is a synthetic intermediate. (The product is for research purpose only.)
References
- The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase
- Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-κB activation and gene expression
- S. K. Manna, B. B. Aggarwal, J. Immunol. 1999, 162, 2095.
- Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
- Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide
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