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CAS RN: 68047-06-3 | Product Number: H1693

(Z)-4-Hydroxytamoxifen


Purity: >95.0%(HPLC)
Synonyms:
  • (Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-en-1-yl]phenol
  • 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
Product Documents:
10MG
NT$6,000
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Product Number H1693
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__2__6H__2__9NO__2 = 387.52 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (<0°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Hygroscopic,Heat Sensitive
CAS RN 68047-06-3
Reaxys Registry Number 4910748
MDL Number

MFCD00468090

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 95.0 area%
Melting point 152.0 to 156.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 154 °C
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H360 : May damage fertility or the unborn child.
H362 : May cause harm to breast-fed children.
H350 : May cause cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P263 : Avoid contact during pregnancy/ while nursing.
P260 : Do not breathe dusts or mists.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# SL1210000
Transport Information:
H.S.code* 2922.19-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
(Z)-4-Hydroxytamoxifen: An Active Metabolite of the Estrogen Receptor Modulator (SERM) Tamoxifem

Tamoxifen citrate [T2510] is a widely used non-steroidal antiestrogen agent for the treatment of hormone-dependent breast cancer. Tamoxifen is a prodrug and it is extensively metabolized by cytochrome P450 (CYP450) enzymes to active metabolites including (Z)-4-hydroxytamoxifen and endoxifen (4-hydroxy-N-desmethyltamoxifen). Each acts as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM) because it acts as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)

References


Application
CRISPR Genome Editing

(Z)-4-Hydroxytamoxifen enhances CRISPR-mediated homology-directed repair (HDR) efficiency.1-4)

References


Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Other Documents

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