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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 608141-41-9 | Product Number: A3669
Apremilast
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxoisoindolin-4-yl]acetamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
NT$3,000
|
7 | 3 | Contact Us | |
| 5G |
NT$10,360
|
19 | 0 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | A3669 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4N__2O__7S = 460.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 608141-41-9 |
| Reaxys Registry Number | 12446985 |
| MDL Number | MFCD18782607 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 155.0 to 159.0 °C |
| Specific rotation | +26.0 to +30.0 deg(C=2, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 157 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Tetrahydrofuran, Acetone, dichloromethane |
| Solubility (insoluble in) | Toluene |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
Transport Information:
| H.S.code* | 2930.90-900 |
Application
Apremilast: A cAMP Phosphodiesterase-4 Inhibitor
Phosphodiesterase-4 (PDE4), primarily found in immune, epithelial and brain cells, is an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. PDE4 participates in the regulation of the inflammatory response by degrading adenosine 3', 5'-cyclicmonophosphate (cAMP) [A2381, A2112 (Na salt)], a key second messenger. Inhibition of PDE4 increases intracellular cAMP levels, resulting in a decrease in pro-inflammatory mediators and an increase in anti-inflammatory mediators. Apremilast is an oral, small molecule inhibitor of PDE4 that is specific for cAMP. PDE4 inhibition results in increased intracellular cAMP levels. In clinical use, apremilast is approved for the treatment of inflammatory diseases, psoriasis and psoriatic arthritis. (The product is for research purpose only.)
References
- Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast Apremilast ), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor
- Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis
- Apremilast mechanism of action and application to psoriasis and psoriatic arthritis (a review)
- Analytical Methods for Determination of Apremilast from Bulk, Dosage Form and Biological Fluids: A Critical Review
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