Maximum quantity allowed is 999
Please select the quantity
CAS RN: 166518-60-1 | Product Number: A3594
Avasimibe
×
![]()
×
Purity: >98.0%(HPLC)
Synonyms:
- 2,6-Diisopropylphenyl [2-(2,4,6-Triisopropylphenyl)acetyl]sulfamate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
NT$4,360
|
≥40 | 0 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | A3594 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__9H__4__3NO__4S = 501.73 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 166518-60-1 |
| Reaxys Registry Number | 7608606 |
| MDL Number | MFCD00934956 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 172.0 to 176.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 174 °C |
GHS
Related Laws:
| RTECS# | CY1482550 |
Transport Information:
| H.S.code* | 2929.90-000 |
Application
Avasimibe: An Orally Bioavailable Inhibitor of ACAT (SOAT)
Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT, also known as sterol O-acyltransferase or SOAT) is an intracellular enzyme that catalyzes the formation of cholesteryl esters from cholesterol and fatty acyl-CoA. Avasimibe (Cl-1011) is an orally bioavailable inhibitor of ACAT. Animal studies have shown that ACAT inhibitors, including avasimibe, reduce plasma cholesterol levels by suppressing the absorption of dietary cholesterol.1,2) Recently, many studies have suggested that ACAT-1 (SOAT-1) plays a critical role in cancer initiation and progression and is an attractive target for novel anticancer therapy. The inhibitor avasimibe has been shown to have antitumor activity.3,4) (The product is for research purpose only.)
Reference
- 1) Pharmacology of the ACAT inhibitor avasimibe (CI-1011) (a review)
- 2) Inhibitors of acyl-coenzyme A: Cholesterol acyltransferase (a review)
- 3) Targeting human Acyl-CoA:cholesterol acyltransferase as dual viral and T cell metabolic checkpoint
- 4) Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.