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CAS RN: 480-44-4 | Product Number: A3013
Acacetin
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Purity: >98.0%(GC)
Synonyms:
- 5,7-Dihydroxy-4'-methoxyflavone
- Apigenin 4'-Methyl Ether
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25MG |
NT$4,120
|
16 | ≥40 |
| 100MG |
NT$11,880
|
8 | ≥100 |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | A3013 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__2O__5 = 284.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 480-44-4 |
| Reaxys Registry Number | 277879 |
| PubChem Substance ID | 354334663 |
| Merck Index (14) | 13 |
| MDL Number | MFCD00016936 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(GC) | min. 98.0 % |
Properties (reference)
| Melting Point | 269 °C |
| Maximum Absorption Wavelength | 335(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | DJ3002000 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Acacetin: An O-Methylated Flavone with Many Biological Activities
Acacetin is an O-methylated flavone in the traditional Chinese medicine Xuelianhua and many plants as a bioactive compound. Recently, the biological properties of acacetin have been reported, such as anti-peroxidative, anti-inflammatory and anti-cancer effects, and etc. For example, acacetin can show to induce G2/M cell-cycle arrest in human colon cancer cell lines. Acacetin can also suppress ultrarapid delayed rectifier K+ current and other cardiac ionic currents, so preventing atrial fibrillation in an atrium-selective way. (The product is for research purpose only.)
References
- Metabolism of apigenin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro
- Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice
- Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines
- Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-jun activation
- Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs
- Column-switching high-performance liquid chromatographic assay for determination of apigenin and acacetin in human urine with ultraviolet absorbance detection
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