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CAS RN: 133550-35-3 | Product Number: A2704
Tyrphostin AG 494
![Tyrphostin AG 494 No-Image](/medias/A2704.jpg?context=bWFzdGVyfHJvb3R8NDMyMTl8aW1hZ2UvanBlZ3xhRE01TDJnME1DODRPVEU1TmpjMk1qSXpOVEU0TDBFeU56QTBMbXB3Wnd8ODA5NmM2NDg3NDBmZTkxNmE3ZTc3NjM4ZWYzYjYxMzZmNTU1M2QxNjA3NmZkMmMzYTE5YTM5YzQzMmY3YjBjYg)
Purity: >98.0%(HPLC)(N)
Synonyms:
- (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide
Product Documents:
Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
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---|---|---|---|---|---|
20MG |
NT$3,040
|
4 | 34 | Contact Us | |
100MG |
NT$10,600
|
2 | 26 | Contact Us |
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Product Number | A2704 |
Purity / Analysis Method | >98.0%(HPLC)(N) |
Molecular Formula / Molecular Weight | C__1__6H__1__2N__2O__3 = 280.28 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Refrigerated (0-10°C) |
Condition to Avoid | Light Sensitive,Heat Sensitive |
CAS RN | 133550-35-3 |
Reaxys Registry Number | 4322707 |
PubChem Substance ID | 253661368 |
MDL Number | MFCD00209863 |
Specifications
Appearance | Light yellow to Amber to Dark green powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(with Total Nitrogen) | min. 98.0 % |
NMR | confirm to structure |
Properties (reference)
Melting Point | 249 °C(dec.) |
GHS
Pictogram |
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Signal Word | Danger |
Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
Transport Information:
UN Number | UN3439 |
Class | 6.1 |
Packing Group | III |
H.S.code* | 2926.90-000 |
Application
Tyrphostin AG 494: A Potent and Selective Inhibitor of EGF Receptor (EGFR) Tyrosine Kinase
Tyrphostin AG 494, a member of tyrosine kinase inhibitors, is a potent and selective inhibitor of EGF receptor (EGFR) tyrosine kinase.
References
- Tyrphostins. II. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases
- Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins.
- Tyrphostin AG 494 blocks Cdk2 activation
- Tyrphostins Protect Neuronal Cells from Oxidative Stress
- Receptor-Guided Alignment-Based Comparative 3D-QSAR Studies of Benzylidene Malonitrile Tyrphostins as EGFR and HER-2 Kinase Inhibitors
- The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells
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