Maximum quantity allowed is 999
Please select the quantity
CAS RN: 446-86-6 | Product Number: A2069
Azathioprine
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
NT$6,120
|
27 | 5 | Contact Us | |
| 25G |
NT$19,200
|
0 | 1 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | A2069 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__7N__7O__2S = 277.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 446-86-6 |
| Reaxys Registry Number | 1225351 |
| PubChem Substance ID | 87559964 |
| Merck Index (14) | 902 |
| MDL Number | MFCD00069203 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 244 °C(dec.) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | UO8925000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Biofilm research
Reference
- The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability
Application
Azathioprine: An Inhibitor of Purine Ribonucleotides and DNA/RNA Synthesis
Azathioprine, a prodrug of 6-mercaptopurine (6-MP) [M0063], was developed by Elion and Hitchings as an immunosuppressant agent for renal transplantation in 1962. They shared the Nobel Prize in 1988. In cell, 6-MP is converted to 6-thioinosine monophosphate (TIMP), catalyzed by hypoxanthine guanine phosphoribosyltransferase (HPRT). TIMP inhibits conversion of inosinic acid to adenylosuccinic acid and xanthylic acid, subsequently leading to inhibition of purine ribonucleotides and DNA/RNA synthesis. Azathioprine and 6-MP are commonly used as an immunosuppressant for treatment of rheumatism, Crohn’s disease and inflammatory bowel disease. (The product is for research purpose only.)
References
- Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues
- Optimisation of Azathioprine Immunosuppression after Organ Transplantation by Pharmacological Measurements
- CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
- Azathioprine: old drug, new actions (a review)
- Thiopurine Therapies: Problems, Complexities, and Progress with Monitoring Thioguanine Nucleotides
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.