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CAS RN: 906093-30-9 | Product Number: M3849
1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine Acetate
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
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$23.00
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| Product Number | M3849 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__8N__4·C__2H__4O__2 = 302.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 906093-30-9 |
| Reaxys Registry Number | 15587953 |
| MDL Number | MFCD28347562 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 119.0 to 123.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 121 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.59-000 |
Application
A Key Synthetic Intermediates of Teneligliptin, a DPP-4 Inhibitor
[M3838] and its acetate [M3849] have been used as key synthetic intermediates of teneligliptin which is a dipeptidylpeptidase IV (DPP-4) inhibitor for use as an orally active antidiabetic agent.1-3) In 2024, Kobayashi et al. reported the synthesis of teneligliptin via a continuous-flow reductive amination of [M3838] using polysilane–Pd catalyst [D5958] or polysilane–Pt catalyst [D5959].3)
References
- 1) Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
- 2) Facile new industrial process for synthesis of teneligliptin through new intermediates and its optimization with control of impurities
- 3) Reductive N-Alkylation of Amines with Ketones Using Heterogeneous Polysilane-Palladium Catalysts under Continuous-Flow Conditions
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