Maximum quantity allowed is 999
Please select the quantity
CAS RN: 89-25-8 | Product Number: M0687
3-Methyl-1-phenyl-5-pyrazolone
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- Monopyrazolone
- Edaravone
- MCI-186
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
$24.00
|
6 | ≥80 | It can be shipped in about 2 weeks after ordering | |
| 500G |
$85.00
|
16 | 8 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | M0687 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__0N__2O = 174.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 89-25-8 |
| Reaxys Registry Number | 609575 |
| PubChem Substance ID | 87572698 |
| SDBS (AIST Spectral DB) | 2704 |
| Merck Index (14) | 6713 |
| MDL Number | MFCD00003138 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 128.0 to 131.0 °C |
| Solubility in N,N-DMF | almost transparency |
| Suitability for cyan-analysis | to pass test |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 129 °C |
| Boiling Point | 287 °C/265 mmHg |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Benzene, Alcohol, Chloroform, Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UQ9625000 |
Transport Information:
| H.S.code* | 2933.19-000 |
Application
Edaravone: A Strong Free Radical Scavenger and a Powerful Antioxidant
Edaravone (MCI-186) is a strong free radical scavenger and a powerful antioxidant. There have been many reports describing that free radicals such as hydroxyl radical (·OH) play a major causative role in the development of cerebral vascular disorder resulting from ischaemia. During ischaemia or ischemic reperfusion, the hyperactivity of a metabolic system of arachidonic acid increases the production of free radicals. These free radicals peroxidize unsaturated fatty acid of cell membrane lipids leads to cell membrane injury. Besides, oxidative stress is believed to contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). Edaravone inhibits lipid peroxidation, and thereby prevents oxidative damage to brain cells or neurons. Consequently, edaravone improves of neurological symptoms, and inhibits the progression of ALS. (The product is for research purpose only.)
References
- High-performance liquid chromatography of reducing carbohydrates as strongly ultraviolet-absorbing and electrochemically sensitive 1-phenyl-3-methyl-5-pyrazolone derivatives
- Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions
- Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model
- Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury (a review)
- Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases
- Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.