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CAS RN: 1953-04-4 | Product Number: G0293
Galantamine Hydrobromide
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$125.00
|
≥40 | 7 | Contact Us | |
| 1G |
$670.00
|
25 | 0 | Contact Us |
* Please contact our distributors or
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | G0293 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__1NO__3·HBr = 368.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic,Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1953-04-4 |
| Related CAS RN | 357-70-0 |
| Reaxys Registry Number | 3787265 |
| PubChem Substance ID | 87558740 |
| Merck Index (14) | 4340 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -92.0 to -98.0 deg(C=1.4, H2O) |
Properties (reference)
| Melting Point | 256 °C |
| Specific Rotation | -95° (C=1.4,H2O) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | DF8045500 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| H.S.code* | 2939.79-000 |
Application
Galantamine Hydrobromide: A Unique Dual Mode Agent, an Inhibitor of Acetylcholinesterase and an Allosteric Modulator of Nicotinic Acetylcholine Receptors
Galantamine, a tertiary alkaloid found in the bulbs of Galanthus woronowi. Galantamine increases the concentration of acetylcholine (ACh) in brain tissue through competitive and reversible inhibition of its hydrolysis by acetylcholinesterase (AChE). Besides, galantamine stimulates nicotinic acetylcholine receptors (nAChR) as an allosteric potentiating ligand (APL) to enhance brain cholinergic function. Therefore, galantamine has shown potential for the treatment of Alzheimer's disease. Galantamine is metabolized in the liver via cytochrome P450 enzymes CYP2D6 and CYP3A4. (The product is for research purpose only.)
References
- Galantamine - a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease (a review)
- Galanthamine, a natural product for the treatment of alzheimer's disease (a review)
- Synthesis and pharmacology of galantamine
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