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CAS RN: 24584-09-6 | Product Number: D4227
Dexrazoxane
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Purity: >98.0%(T)
Synonyms:
- (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
- (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|---|---|---|---|---|---|
| 100MG |
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2 | 0 | Contact Us |
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| Product Number | D4227 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__1H__1__6N__4O__4 = 268.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 24584-09-6 |
| Reaxys Registry Number | 6658412 |
| PubChem Substance ID | 160871504 |
| Merck Index (14) | 8123 |
| MDL Number | MFCD00866449 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 193.0 to 197.0 °C |
| Specific rotation [a]20/D | +10.0 to +13.0 deg(C=5、DMF) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 195 °C |
| Specific Rotation | 11° (C=5,DMF) |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Ethanol, Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | TL6390000 |
Transport Information:
| H.S.code* | 2933.59-000 |
Application
Studies on the Topoisomerase II Inhibitory Effects of Dexrazoxane
References
- Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(±)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane)
- G. J. Gorbsky, Cancer Res. 1994, 54, 1042.
- Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle
- A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines
- A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane)
- Topoisomerase IIbeta-Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane
Application
Studis of Cardiotoxicity Reduction
References
- Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane
- Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines
- B. B. Hasinoff, K. Hellmann, E. H. Herman, V. J. Ferrans, Curr. Med. Chem. 1998, 5, 1.
PubMed Literature
Articles/Brochures
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Safety Data Sheet (SDS)
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Specifications
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