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CAS RN: 177036-94-1 | Product Number: A2966
Ambrisentan
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Purity: >98.0%(HPLC)
Synonyms:
- (S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic Acid
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 20MG |
$50.00
|
18 | 12 | Contact Us | |
| 100MG |
$176.00
|
15 | ≥40 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | A2966 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__2N__2O__4 = 378.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 177036-94-1 |
| PubChem Substance ID | 354333648 |
| Merck Index (14) | 384 |
| MDL Number | MFCD09842330 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +170 to +176 deg(C=0.5, MeOH) |
Properties (reference)
| Melting Point | 178 °C(dec.) |
| Specific Rotation | 173° (C=0.5,MeOH) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol, Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | UA2459660 |
Transport Information:
| H.S.code* | 2933.59-000 |
Application
Ambrisentan: A Selective ETA Receptor Antagonist
Endothelin-1 (ET-1) is a peptide that constricts pulmonary blood vessels and raise blood pressure. Two ET-1 receptor subtypes, ETA and ETB, mediate the effects of ET-1 in the vascular smooth muscle and endothelium. The actions of ETA would be vasoconstriction and cell proliferation, while the actions of ETB would be vasodilatation, antiproliferation, and ET-1 clearance. Ambrisentan is a highly selective ETA receptor antagonist with >4000-fold higher selectivity over the ETB receptor. Pulmonary arterial hypertension (PAH) would be derived from the action of ETA receptor. Therefore, ambrisentan is used for the treatment of PAH. For your reference, [H1568] is a key synthetic intermediate of ambrisentan. (The product is for research purpose only.)
References
- Discovery and Optimization of a Novel Class of Orally Active Nonpeptidic Endothelin-A Receptor Antagonists
- Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future?
- The endothelin system in pulmonary arterial hypertension
- Endothelin receptor antagonists in pulmonary arterial hypertension (a review)
- Ambrisentan (a review)
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